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Prof Douglas Steele

 

MD, PhD, MRCPsych

Honorary Consultant Psychiatrist

Professor of Neuroimaging

Co-Director, Clinical Research Imaging Facility

School of Medicine (Neuroscience)
University of Dundee
Ninewells Hospital and Medical School
Dundee DD1 9SY

Tel: *44-1382-496-233
Fax:*44-1382-633-865

Professor of NeuroImaging, University of Dundee

 

Honorary Consultant Psychiatrist, Dundee and London

 

SINAPSE, Clinical Research Imaging Facility (CRIF)

Research and Clinical Interests, Publication Metrics, Psychiatric Neuroimaging Definition

 


Selected Publications

Tolomeo, S., Christmas, D., Jentzsch, I., Johnston, B., Sprenglemeyer, R., Matthews, K., Steele, J.D. (2016) “A Causal Role for the Anterior Mid-Cingulate Cortex in Negative Affect and Cognitive Control”  Brain (in press)

 

Johnston, B.A.., Tolomeo, S, Gradin, V., Christmas, D., Matthews, K., Steele J.D. (2015) “Failure of Hippocampal Deactivation during Loss Events in Treatment-Resistant Depression” Brain 138(9) 2766-76

 

Gradin V., Baldacchino A., Balfour D., Matthews K, Steele J.D. (2014) “Abnormal Brain Activity during a Reward and Loss Task in Opiate Dependent Patients receiving Methadone Maintenance Therapy” Neuropsychopharmacology 39(4):885-94

Mwangi, B., Ebmeier K.P., Matthews, K.M., Steele, J.D. (2012) "Multicentre Diagnostic Classification of Individual Structural Neuroimaging Scans from Patients with Major Depressive Disorder", Brain 135(1) 1508-21

Perrin, J., Merz, S., Bennett, D.., Currie, J., Steele J.D., Reid I., Schwarzbauer C. (2012) "Electroconvulsive Therapy Reduces Frontal Connectivity in Severe Depression", Proc Natl Acad Sci USA 109(14) 5464-8

Gradin, V., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., Steele, J.D. (2011) "Expected Value and Prediction Error Abnormalities in Depression and Schizophrenia", Brain 134(6) 1751-1764

Kumar P, Waiter G, Ahearn T, Milders M, Reid I, Steele J.D. (2008) “Abnormal temporal difference reward-learning signals in major depression” Brain, 131(8) 2084-2093

Rück C, Karlsson A, Steele J.D., Edman G, Meyerson B.A., Ericson K, Nyman H, Åsberg M, Svanborg P (2008) "Capsulotomy for Obsessive-Compulsive Disorder – long-term follow-up of 25 patients" JAMA Psychiatry, 65(8), 914-921

Steele J.D., Christmas D., Eljamel M.S., Matthews K. (2008) “Anterior cingulotomy for major depression: Clinical outcome and relationship to lesion characteristics” Biological Psychiatry, 63(7), 670-677

Steele J.D., Kumar P., Ebmeier, K.P. (2007) “Blunted response to feedback information in depressive illness”, Brain, 130 (9), 2367-74

Ebmeier K., Donaghey C., Steele J.D. (2006) “Recent Developments and Current Controversies in Depression”, Lancet, 367, 153-167

 

 

Publications

2016

 

Tolomeo, S., Christmas, D., Jentzsch, I., Johnston, B., Sprenglemeyer, R., Matthews, K., Steele, J.D. (2016) “A Causal Role for the Anterior Mid-Cingulate Cortex in Negative Affect and Cognitive Control”  Brain (in press)

 

Gradin, V.B., Perez, A., Macfarlane, J., Cavin, I., Waiter, G., Tone, E., Dritschel, B., Maiche, A., Steele, J.D. (2015) “Neural Correlates of Social Exchanges during the Prisoner’s Dilemma Game in Depression” Psychological Medicine (in press)

 

Tolomeo, S., Gray, S., Matthews, K., Steele, J.D., Baldacchino A. (2016) “Multifaceted Impairments in Impulsivity and Brain Structural Abnormalities in Opioid Dependence and Abstinence” Psychological Medicine (in press)

 

 

2015

 

Johnston, B.A.., Tolomeo, S, Gradin, V., Christmas, D., Matthews, K., Steele J.D. (2015) “Failure of Hippocampal Deactivation during Loss Events in Treatment-Resistant Depression” Brain 138(9) 2766-76

 

Johnston, B.A., Coghill, D., Matthews, K., Steele, J.D. (2015) "Predicting Methylphenidate Response in Attention Deficit Hyperactivity Disorder: a Preliminary Study" Journal of Psychopharmacology 29(1), 24-30

Gradin V., Perez A., MacFarlane J., Cavin I., Waiter G., Engelman  J., Dritschel B., Pomi A., Matthews K., Steele J.D. (2015) “Abnormal Responses to Unfairness in Depression: An fMRI Study using the Ultimatum Game” Psychological Medicine 45(6):1241-51

 

Johnston, B.A., Steele, J.D., Tolomeo, S., Christmas, D., Matthews, K.M. (2015) ‘Structural MRI-based predictions with Treatment-Refractory Depression’ Plos One (in press)

 

2014

 

Gradin V., Baldacchino A., Balfour D., Matthews K, Steele J.D. (2014) “Abnormal Brain Activity during a Reward and Loss Task in Opiate Dependent Patients receiving Methadone Maintenance Therapy” Neuropsychopharmacology 39(4):885-94

 

Johnston, B.A., Mwangi, B., Matthews, K., Coghill, D., Konrad, K., Steele, J.D. (2014) “Brainstem Abnormalities in ADHD Support High Accuracy Individual Diagnostic Classification” Human Brain Mapping 35(10:5179-89

 

Sokunbi, M.O., Gradin, V.B., Waiter, G.D., Cameron, G.G., Ahearn, T.S., Murray, A.D., Steele J.D., Staff, R.T. (2014) “Nonlinear Complexity Analysis of Brain fMRI Signals in Schizophrenia”, Plos One 9(8) DOI: 10.1371/journal.pone.0095146

 

2013

 

Christmas, D., Steele, J.D., Tolomeo, S., Eljamel, M.S., Matthews, K.M. (2013) "Vagus Nerve Stimulation for Chronic Major Depressive Disorder: 12-Month Outcomes in Highly Treatment-Refractory Patients" Journal of Affective Disorders 150(3):1221-5

 

Brydges, N.M., Whalley, H.C., Jansen, M.A., Merrifield, G.D., Wood, E.R., Lawrie, S.L., Wynne, S., Day, M., Fleetwood-Walker, S., Steele, J.D., Marshall, I., Hall, J., Holmes, M.C. (2013) "Imaging Conditioned Fear Circuitry Using Awake Rodent fMRI", PLoS One 8(1): e54197 doi:10.1371/journal.pone.0054197

 

Johnston, BA., Mwangi, B.,  Matthews, K.,  Coghill, D.,  Steele, JD. (2013) "Predictive Classification of Individual Magnetic Resonance Imaging Scans from Children and Adolescents."  Eur Child Adoles Psy 22:12 733-744

 

Gradin V., Waiter G., O'Connor A., Romaniuk L., Stickle C., Matthews K., Hall J., Steele J.D. (2013) "Salience network-midbrain dysconnectivity and blunted signals in schizophrenia", Psychiatry Research: Neuroimaging 211(2) 104-111

 

Browne, S., Christmas, D., Steele, J.D., Eljamel, M.S., Matthews K. (2013) "Other Brain Stimulation Treatments" The ECT Handbook (3rd Edition), Royal College of Psychiatrists

 

2012

Mwangi, B., Ebmeier K.P., Matthews, K.M., Steele, J.D. (2012) "Multicentre Diagnostic Classification of Individual Structural Neuroimaging Scans from Patients with Major Depressive Disorder", Brain 135(1) 1508-21

Perrin, J., Merz, S., Bennett, D.., Currie, J., Steele J.D., Reid I., Schwarzbauer C. (2012) "Electroconvulsive Therapy Reduces Frontal Connectivity in Severe Depression", Proc Natl Acad Sci USA 109(14) 5464-8

Gradin, V., Waiter, G., Kumar, P., Stickle, C., Milders, M., Matthews, K., Reid, I., Hall, J., Steele, J.D. (2012) "Social Exclusion in Schizophrenia", PLoS One 7(8): e42608 doi:10.1371/journal.pone.0042608

Christmas, D., Matthews, K., Steele, J.D., MacVicar B. (2012) "Neurosurgery and Neuromodulation for Mental Disorder" Royal College of Psychiatrists, CPD Online: part 1, part 2

Allan CL, Topiwala A, Ebmeier KP, Semple D, Steele J.D. (2012), Chapter 7 "Biological treatment of mood disorders" of Power M. (ed.) Mood Disorders: A Handbook of Science and Practice. John Wiley & Sons, Ltd, New York.

2011

Gradin, V., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., Steele, J.D. (2011) "Expected Value and Prediction Error Abnormalities in Depression and Schizophrenia", Brain 134(6) 1751-1764

Mwangi, B., Matthews, K.M., Steele, J.D. (2011) "Prediction of Illness Severity in Patients with Major Depression using Structural Magnetic Resonance Imaging Scans", Journal of Magnetic Resonance Imaging 35(1) 64-71

Sprengelmeyer, R., Steele, J.D, Mwangi, B., Kumar, P., Christmas, D., Milders, M., Matthews, K. (2011) "The Insular Cortex and the Neuroanatomy of Major Depression", Journal of Affective Disorders 133(1-2) 120-127

Christmas, D., Eljamel, S., Butler, S., Hazari, H., MacVicar, R., Steele, J.D., Livingstone, A., Matthews, K. (2011) "Long-term outcome of thermal anterior capsulotomy for chronic, treatment-refractory depression" Journal of Neurology, Neurosurgery and Psychiatry, 82 594-600

2010

Gradin, V., Gountouna V.E., Job D.E., McIntosh A.M., Moorhead T.W., Lymer G.K., Whalley H.C., Hall J, Waiter G.D., Brennan D, McGonigle D.J., Ahearn T.S., Cavanagh J, Condon B, Hadley D.M., Marshall I, Murray A.D., Wardlaw J.M., Lawrie S.M., Steele J.D. (2010) "Between and within scanner variability in the Calibrain n-back cognitive task" Psychiatry Research: Neuroimaging, 184(2) 86-95

Gountouna V.E., Job D.E., McIntosh A.M., Moorhead T.W., Lymer G.K., Whalley H.C., Hall J, Waiter G.D., Brennan D, McGonigle D.J., Ahearn T.S., Cavanagh J, Condon B, Hadley D.M., Marshall I, Murray A.D., Steele J.D., Wardlaw J.M., Lawrie S.M. (2010) "Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task" NeuroImage, 49(1) 552-560

Steele J.D. and Lawrie S., Chapter 5 “Neuroimaging” of “Companion to Psychiatric Studies” (2010) (ed. Johnstone E.C., Lawrie, S.L. et al), Churchill Livingstone, Edinburgh.

Steele J.D., Chapter 2 “Functional Neuroanatomy” of “Companion to Psychiatric Studies” (2010) (ed. Johnstone E.C., Lawrie, S.L. et al), Churchill Livingstone, Edinburgh

2009

Hall J, Romaniuk L, McIntosh A.M., Steele J.D., Johnstone E.C., Lawrie S.M. (2009) “Associative learning and the genetics of schizophrenia” TINS, 32(6) 359-363

Whalley H, Steele J.D., Mukherjee P, Romaniuk L, McIntosh A, Hall J, Lawrie S (2009) "Connecting the brain and new targets for schizophrenia" Current Pharmaceutical Design, 15(22) 2615-2631

Moorhead W.T., Romaniuk R, Lymer K, Whalley H.C., Waiter G, Brennan D, Ahearn T, Cavanagh J, Condon B, Steele J.D., Wardlaw J.M., Lawrie S.M. (2009) "Prospective multi-centre voxel based morphometry study employing scanner specific segmentations: Procedure development using CaliBrain structural MRI data" BMC Medical Imaging, 9(8) 1-12

Kumar P, Waiter G, Ahearn T, Milders M, Reid I, Steele J.D. (2009) “Frontal operculum temporal difference signals and social motor response learning” Human Brain Mapping, 30, 1421-1430

2008

Kumar P, Waiter G, Ahearn T, Milders M, Reid I, Steele J.D. (2008) “Abnormal temporal difference reward-learning signals in major depression” Brain, 131(8) 2084-2093

Rück C, Karlsson A, Steele J.D., Edman G, Meyerson B.A., Ericson K, Nyman H, Åsberg M, Svanborg P (2008) "Capsulotomy for Obsessive-Compulsive Disorder – long-term follow-up of 25 patients" JAMA Psychiatry, 65(8), 914-921

Steele J.D., Christmas D., Eljamel M.S., Matthews K. (2008) “Anterior cingulotomy for major depression: Clinical outcome and relationship to lesion characteristics” Biological Psychiatry, 63(7), 670-677

2007

Steele J.D., Kumar P., Ebmeier, K.P. (2007) “Blunted response to feedback information in depressive illness”, Brain, 130 (9), 2367-74

Steele J.D., Currie J., Lawrie S.L., Reid I.C. (2007) “Localisation of prefrontal functional abnormality in mood disorder: A stereotactic meta-analysis”, Journal of Affective Disorders, 11, 1-11

Ebmeier, K.P., Rose, E. J., Steele, J.D. (2007) “Cognitive Impairment in Major Depression (the fMRI perspective).” Chapter in "Implications of Comorbidity for Etiology and Treatment of Neuropsychiatric Disorders", Palomo, T., Archer, T., Beninger, R. J. (eds.) Editorial CYM, Madrid

2006

Ebmeier K.P. Rose E. and Steele J.D. (2006) “Cognitive impairment and fMRI in major depression”, Neurotoxicity Research, 10(2), 87-92

Gilbert S.J., Spengler S., Simons J.S., Steele J.D., Lawrie S.M., Frith C.D., Burgess P.W. (2006) “Functional specialisation within rostral prefrontal cortex (area 10): a meta-analysis”, J Cog Neurosci, 18(6), 932-48

Ebmeier K., Donaghey C., Steele J.D. (2006) “Recent Developments and Current Controversies in Depression”, Lancet, 367, 153-167

2005

Steele J.D., Bastin M.E., Wardlaw J.M. and Ebmeier K.P. (2005) “Possible Structural Abnormality of the Brainstem in Unipolar Depressive Illness: A Transcranial Ultrasound and Diffusion Tensor Magnetic Resonance Imaging Study” Journal of Neurology, Neurosurgery and Psychiatry, 76, 1510-1515.

“Depressive Illness and Emotional Learning” Steele J.D. (2005) Current Medical Imaging Reviews, 1(2), 157-176

2004

Steele J.D., Meyer M., Ebmeier K.P. (2004) “Neural Predictive Error Signal Correlates with Depressive Illness Severity in a Game Paradigm” NeuroImage, 23, 269-280

Steele J.D. and Lawrie S. (2004) “Segregation of cognitive and emotional function in the prefrontal cortex: A stereotactic meta-analysis” NeuroImage, 21, 868-875

Steele J.D. and Lawrie S., Chapter 5 “Neuroimaging” of “Companion to Psychiatric Studies” (2004) (ed. Johnstone E.C., Lawrie, S.L. et al), Churchill Livingstone, Edinburgh.

Steele J.D. and Reid I.C., Chapter 2 “Functional Neuroanatomy” of “Companion to Psychiatric Studies” (2004) (ed. Johnstone E.C., Lawrie, S.L. et al), Churchill Livingstone, Edinburgh

2003

Ebmeier KP, Berge A, Semple D, Shah PJ, Steele J.D. (2003), Chapter 7 "Biological treatments of mood disorders" of Power M. (ed.) Mood Disorders: A Handbook of Science and Practice. John Wiley & Sons, Ltd, New York.

2002

Shajahan, P.M., Glabus, M.F., Steele, J.D., Doris, A.B., Anderson, K., Jenkins, J.A., Gooding, P.A. & Ebmeier, K.P.,(2002) “Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depression.” Progress in Neuro-Psychopharmacology and Biological Psychiatry, 26, 945-954.

Soonawala, D, Ebmeier, KP, Steele, J.D., Dougall, NJ, Best, J, Migneco, O, Nobili, F, Scheidhauer, K. (2002) “Statistical Parametric Mapping of 99mTc-HMPAO-SPECT images for the diagnosis of Alzheimer’s disease: normalising to cerebellar tracer uptake” NeuroImage, 17, 1193-1202.

Ebmeier, K.P., Shajahan P.M. and Steele J.D. (2002) “Changes in motor excitability in major depression: state or trait marker?” Biological Psychiatry, 51, 154S.

2000

Steele, J.D., Glabus M.F., Shajahan P.M. and Ebmeier K.P., (2000) “Increased Cortical Inhibition in Depression: a prolonged Silent Period with Transcranial Magnetic Stimulation (TMS)” Psychological Medicine, 30: 565-570

1995 and previously

Ebmeier, K.P. Steele J.D., McKenzie, D.M. O’Carrol, R.E. Kydd, K.E. Glabus, M.F. Blackwood, D.R.H Rugg, M.D. Goodwin G.M. (1995), “Cognitive Brain Potentials and Regional Central Cerebral Blood Flow Equivalents during Two- and Three-Sound Auditory ‘Oddball’ Tasks”Electroencephalography and Clinical Neurophysiology, 95: 434-443

Doris, A. O’Carrol, R.E. Steele, J.D. Ebmeier K.P. (1995), “Single Photon Emission Tomography in a Patient with Unilateral Auditory Hallucinations”, Behavioural Neurology 8: 145-148

Steele, J.D. Dillon, J.F. Pleveris, J.N. Hauer, J.C. Bouchier, I.A.D. Hayes P.C. (1994), "Hand Skin Temperature Changes in Patients with Chronic Liver Disease" Journal of Hepatology, 21: 927-9

Steele, J.D. Titchmarsh, J.M. Chapman, J.N. Paterson J.H. (1985), “A Single-Stage Process for Quantifying Electron-Energy Loss Spectra”, Ultramicroscopy, 17:273

Nicholson, W.A.P. Adam, P.F. Craven, A.J. Steele J.D. (1984), “The Shape of Bremsstrahlung Background in Thin Film X-Ray Spectra”, Analytical Electron Microscopy, 257